子痫前期患者血浆同型半胱氨酸与丙二醛水平的相关性
The correlation between plasma homocysteine and malondialdehyde levels in preeclampsia.
作者信息
Tug Niyazi, Celik Husnu, Cikim Gurkan, Ozcelik Oguz, Ayar Ahmet
机构信息
Obstetrics and Gynecology Department, Firat University School of Medicine, Elazig, Turkey.
出版信息
Neuro Endocrinol Lett. 2003 Dec;24(6):445-8.
OBJECTIVE
To investigate the possible correlation between plasma malondialdehyde and homocysteine levels of preeclamptic patients.
DESIGN
Venous blood samples of 20 preeclamptics and 20 healthy pregnant controls were collected. Plasma malondialdehyde and homocysteine concentrations were measured and the correlation between them was investigated. Mann Whitney U test and Spearman correlation analysis were used for statistical analysis.
SETTING
University of Firat, Medical School.
RESULTS
Plasma malondialdehyde and homocysteine concentrations were higher in preeclamptic patients (p<0.05) and a positive correlation between these parameters was found (r: 0.77, p<0.01, n:20).
CONCLUSION
Our results may put forward some new strategies in the research of etiopathogenesis and treatment of preeclampsia.
目的
探讨子痫前期患者血浆丙二醛水平与同型半胱氨酸水平之间可能存在的相关性。
设计
采集20例子痫前期患者及20例健康孕妇对照组的静脉血样本。测定血浆丙二醛和同型半胱氨酸浓度，并研究二者之间的相关性。采用曼-惠特尼U检验和斯皮尔曼相关性分析进行统计学分析。
地点
菲拉特大学医学院。
结果
子痫前期患者血浆丙二醛和同型半胱氨酸浓度较高（p<0.05），且发现这些参数之间存在正相关（r：0.77，p<0.01，n=20）。
结论
我们的研究结果可能为子痫前期的病因发病机制及治疗研究提出一些新策略。
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