Al-Sakarneh Nawal Ahmad, Mashal Rima Hussein
Food Physical Laboratory Division, Administration Laboratories Directoraite, Jordan Food and Drug Administration (JFDA), Amman 11942, Jordan.
Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Amman 11942, Jordan.
Prev Nutr Food Sci. 2021 Mar 31;26(1):21-29. doi: 10.3746/pnf.2021.26.1.21.
Pre-eclampsia (PE) is considered a major complication of pregnancy. Hyperhomocyteinemia (H-Hcy) has been proposed to be associated with a number of placenta-mediated diseases, such as PE. Zinc (Zn) is involved in the regulation of total homocysteine (Hcy) levels. A case-control study design was used to examine serum Zn and Hcy statuses, and their association to PE risk. Thirty pregnant women with PE 21∼35 years of age, and 30 matched healthy pregnant women were recruited from Amman, Jordan. Plasma Hcy was measured using liquid chromatography-mass spectrometry, and Zn was measured using atomic absorption. Hcy levels were significantly higher among women with PE compared with controls (16.35±0.43 and 7.25±0.21 μmol/L, respectively; <0.05). However, there was no significant difference in Zn levels between women with PE and controls (65.37±1.27 and 63.71±1.24 μg/dL, respectively; >0.05). Blood levels of Hcy (μmol/L) were positively associated with systolic and diastolic blood pressure (β=3.54 and β=1.81, respectively; <0.05), and Zn levels [odds ratios (OR)=0.84; 95% confidence intervals (CI): 0.71∼0.98] were significantly associated with PE risk (<0.05). Although women with PE had significantly higher Hcy levels than controls, H-Hcy was not associated with increased PE risk. However, there was a strong association between severity of hypertension and serum Hcy levels, and serum Zn levels were inversely associated with H-Hcy. The likelihood of PE was significantly higher in women who were Zn deficient compared with healthy controls. To conclude, early management of H-Hcy and associated risk factors may be effective in decreasing the incidence of PE.
子痫前期（PE）被认为是妊娠的一种主要并发症。高同型半胱氨酸血症（H-Hcy）被认为与多种胎盘介导的疾病有关，如子痫前期。锌（Zn）参与总同型半胱氨酸（Hcy）水平的调节。本研究采用病例对照研究设计，以检测血清锌和同型半胱氨酸状态及其与子痫前期风险的关联。从约旦安曼招募了30名年龄在21至35岁之间的子痫前期孕妇和30名匹配的健康孕妇。采用液相色谱-质谱法测定血浆同型半胱氨酸，采用原子吸收法测定锌。与对照组相比，子痫前期女性的同型半胱氨酸水平显著更高（分别为16.35±0.43和7.25±0.21μmol/L；P<0.05）。然而，子痫前期女性与对照组的锌水平无显著差异（分别为65.37±1.27和63.71±1.24μg/dL；P>0.05）。血液中同型半胱氨酸水平（μmol/L）与收缩压和舒张压呈正相关（β分别为3.54和1.81；P<0.05），锌水平[比值比（OR）=0.84；95%置信区间（CI）：0.71至0.98]与子痫前期风险显著相关（P<0.05）。虽然子痫前期女性的同型半胱氨酸水平显著高于对照组，但高同型半胱氨酸血症与子痫前期风险增加无关。然而，高血压严重程度与血清同型半胱氨酸水平之间存在强关联，血清锌水平与高同型半胱氨酸血症呈负相关。与健康对照组相比，锌缺乏女性患子痫前期的可能性显著更高。总之，早期管理高同型半胱氨酸血症及相关危险因素可能有效降低子痫前期的发病率。
