Shishido H, Nagai H, Kawakami K
Department of Respiratory Diseases, Tokyo National Chest Hospital.
Nihon Rinsho. 1992 May;50(5):1075-80.
Sputum isolates of MRSA have been on the increase, recently. Preventive measures against MRSA nosocomial infections have become important in Japanese hospitals. Clinical study was performed on 29 patients from whom MRSA was isolated more than 10(7) cfu/ml using the quantitative sputum culture method. All had a history of admission, therefore nosocomial infections caused by MRSA could very often occur. MRSA was determined as a causative organism in 3 on the basis of symptoms, laboratory data, chest X-rays, and effect of antimicrobial agents. These three patients improved by a single or combined administration of minocycline, arbekacin and/or fosfomycin. In 15 patients, MRSA was frequently isolated, but was thought to be colonized. In 3 patients, MRSA was not isolated without administration of antimicrobial agents thereafter. It was supposed that most of MRSA isolates from sputum were not the causative organism of the respiratory tract infection.
近年来，耐甲氧西林金黄色葡萄球菌（MRSA）的痰液分离株一直在增加。在日本医院，针对MRSA医院感染的预防措施变得至关重要。使用定量痰液培养方法对29例痰液中MRSA分离量超过10（7）cfu/ml的患者进行了临床研究。所有患者都有住院史，因此由MRSA引起的医院感染经常发生。根据症状、实验室数据、胸部X光片和抗菌药物的疗效，确定3例患者的病原体为MRSA。这3例患者通过单一或联合使用米诺环素、阿贝卡星和/或磷霉素后病情好转。15例患者经常分离出MRSA，但被认为是定植菌。3例患者在之后未使用抗菌药物的情况下未分离出MRSA。据推测，痰液中分离出的大多数MRSA不是呼吸道感染的病原体。
