Miyachi N, Ishikawa M, Ohishi F
Department of Pharmacy, Tachikawa Sohgo Hospital.
Nihon Rinsho. 1992 May;50(5):1010-5.
A strain of Methicillin-Resistant Staphylococcus aureus (MRSA) was first isolated in our hospital in March 1986. Since then, MRSA has become a difficult pathogen and a cause of sepsis, bacterial endocarditis, and pneumonia in 1988. Rigorous hospital-wide control measures have been planned. The major control measures, based on the various investigations reported, consist of the following three points; improvement of environmental control, reinforcement of handwashing practices during care and control usage of antibiotics. The frequency of isolation of MRSA among the S. aureus isolates was 43.3% in 1988 and this was further reduced to 31.7% in 1990. The total number of MRSA isolates from decubitus, bile, and blood samples have also declined. This decline resulted in a reduction of cases of severe MRSA infection. As yet, MRSA strain are still isolated on incubation. There may be a limit to complete control by measures in a single hospital. It is desired that regional measures and national consensus on nosocomial infection be established.
1986年3月，我院首次分离出一株耐甲氧西林金黄色葡萄球菌（MRSA）。从那时起，MRSA成为一种难以对付的病原体，并在1988年导致败血症、细菌性心内膜炎和肺炎。已制定了全院范围的严格控制措施。根据所报告的各种调查，主要控制措施包括以下三点：改善环境控制、加强护理期间的洗手措施以及控制抗生素的使用。1988年，金黄色葡萄球菌分离株中MRSA的分离频率为43.3%，1990年进一步降至31.7%。来自褥疮、胆汁和血液样本的MRSA分离株总数也有所下降。这种下降导致严重MRSA感染病例减少。然而，仍有MRSA菌株在培养时被分离出来。仅靠一家医院的措施可能无法完全控制。希望能制定区域措施并就医院感染达成全国共识。
