Lamba Harpal, Goldmeier David, Mackie Nicola E, Scullard George
Department of HIV Medicine & Sexual Health, St Mary's Hospital, Paddington, London W2 INY, UK.
Int J STD AIDS. 2004 Apr;15(4):234-7. doi: 10.1258/095646204773557749.
Our objective was to determine the relationship between highly active antiretroviral therapy (HAART), serum total oestradiol and sexual dysfunction in HIV-infected men. Sexual difficulties were recorded prospectively in a cohort of HIV-negative (or unknown status) gay/bisexual men (MSM) and a cohort of HIV-infected men. The HIV-infected men were divided into those on and not on HAART and by sexuality. Serum total oestradiol and testosterone levels were evaluated where possible. One hundred HIV-negative MSM and 73 HIV-infected men (88% MSM) were analysed. Low libido and erectile dysfunction (ED) were reported in the control group in 2% and 10% respectively. This compared to a prevalence of 26% for both problems in HIV-infected MSM not taking HAART. In those MSM on HAART reduced libido was noted in 48% and ED in 25%. In the group of men taking HAART the mean oestradiol level was 228 pmol/L and was significantly above normal limits. Low libido and ED are more commonly reported in HIV-infected men compared to gay men of negative or unknown status. HAART is associated with a higher prevalence of lack of sexual desire and raised serum oestradiol levels.
我们的目的是确定高效抗逆转录病毒疗法（HAART）、血清总雌二醇与HIV感染男性性功能障碍之间的关系。前瞻性记录了一组HIV阴性（或感染状况未知）的男同性恋者/双性恋男性（MSM）以及一组HIV感染男性的性困难情况。将HIV感染男性按是否接受HAART以及性取向进行分组。尽可能评估血清总雌二醇和睾酮水平。对100名HIV阴性MSM和73名HIV感染男性（88%为MSM）进行了分析。对照组中分别有2%和10%的人报告有性欲低下和勃起功能障碍（ED）。相比之下，未接受HAART的HIV感染MSM中这两个问题的患病率为26%。在接受HAART的MSM中，48%的人有性欲减退，25%的人有ED。在接受HAART的男性组中，平均雌二醇水平为228 pmol/L，显著高于正常范围。与HIV阴性或感染状况未知的男同性恋者相比，HIV感染男性中更常报告有性欲低下和ED。HAART与性欲缺乏的较高患病率以及血清雌二醇水平升高有关。
