Habib Amgad R, Fernando Rufus
Department of Genitourinary Medicine, New Cross Hospital, Wednesfield Road, Wolverhampton WV10 0QP, UK.
Int J STD AIDS. 2004 Apr;15(4):240-2. doi: 10.1258/095646204773557767.
This paper describes the efficacy of azithromycin 1g single dose in the management of uncomplicated gonorrhoea either with or without chlamydial co-infection. Three hundred and one patients were treated for gonorrhoea between January 2000 and June 2001; 226/301 (75.1%) were treated with azithromycin 1g stat dose while the rest were treated with different regimens. Ninety-seven of 301 (32.2%) of all isolated strains were found to be resistant to at least one antibiotic where penicillin constituted the majority (23%). Chlamydial co-infection was found in 38.2% (115/301). Only 73.1% (220/301) attended for a test-of-cure, all but six patients had negative gonorrhoea cultures at their reviews. Among the six failures 3/32 (9.3%) were initially on amoxicillin, 2/170 (1.2%) on azithromycin and 1/22 (4.5%) on ciprofloxacin. Hence, azithromycin stat dose has proved to be a cost-effective treatment for uncomplicated gonorrhoea supported by the increased prevalence of penicillin-resistant organisms, concomitant chlamydial infection and the high failure rate in keeping review appointments.
本文描述了单剂量1克阿奇霉素在治疗单纯性淋病（无论有无衣原体合并感染）中的疗效。2000年1月至2001年6月期间，301例患者接受了淋病治疗；226/301（75.1%）接受了单剂量1克阿奇霉素治疗，其余患者接受了不同方案的治疗。在所有分离出的菌株中，301例中有97例（32.2%）被发现对至少一种抗生素耐药，其中以青霉素耐药为主（23%）。衣原体合并感染率为38.2%（115/301）。只有73.1%（220/301）的患者接受了治愈检测，除6例患者外，其余患者复查时淋病培养均为阴性。在6例治疗失败的患者中，3/32（9.3%）最初使用阿莫西林，2/170（1.2%）使用阿奇霉素，1/22（4.5%）使用环丙沙星。因此，鉴于耐青霉素菌株的患病率增加、衣原体合并感染以及复查预约的高失约率，单剂量阿奇霉素已被证明是一种治疗单纯性淋病的具有成本效益的疗法。
