在构巢曲霉中，铁载体的生物合成和摄取受PacC介导的环境pH调节系统控制。
Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient-pH Regulatory system in Aspergillus nidulans.
作者信息
Eisendle Martin, Oberegger Harald, Buttinger Rudolf, Illmer Paul, Haas Hubertus
机构信息
Department of Molecular Biology, Medical University of Innsbruck, Austria.
出版信息
Eukaryot Cell. 2004 Apr;3(2):561-3. doi: 10.1128/EC.3.2.561-563.2004.
Abstract
Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system is elevated by an increase in the ambient pH. Mediation of this regulation by the transcriptional regulator PacC has been confirmed via acidity- and alkalinity-mimicking mutants.
摘要
构巢曲霉中铁载体的生物合成和摄取不仅受铁可用性的调节，还受环境pH值的调节：环境pH值升高会提高这种高亲和力铁摄取系统的表达。转录调节因子PacC对这种调节的介导已通过模拟酸性和碱性的突变体得到证实。
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