Monocyte chemoattractant protein-1: a key mediator of angiotensin II-induced target organ damage in hypertensive heart disease?
作者信息
Zhuo Jia L
出版信息
J Hypertens. 2004 Mar;22(3):451-4. doi: 10.1097/01.hjh.0000098211.37783.e7.
Abstract
摘要
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Monocyte chemoattractant protein-1: a key mediator of angiotensin II-induced target organ damage in hypertensive heart disease?单核细胞趋化蛋白-1：高血压性心脏病中血管紧张素II诱导的靶器官损伤的关键介质？
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Eprosartan improves cardiac performance, reduces cardiac hypertrophy and mortality and downregulates myocardial monocyte chemoattractant protein-1 and inflammation in hypertensive heart disease.
J Hypertens. 2004 Mar;22(3):583-92. doi: 10.1097/00004872-200403000-00022.
2
Are there benefits to specific antihypertensive drug therapy?特定的抗高血压药物治疗有什么益处吗？
Am J Hypertens. 2003 Nov;16(11 Pt 2):31S-35S. doi: 10.1016/j.amjhyper.2003.07.004.
3
Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney.血管紧张素II调节肾脏中促炎细胞因子和趋化因子的合成。
Kidney Int Suppl. 2002 Dec(82):S12-22. doi: 10.1046/j.1523-1755.62.s82.4.x.
4
Angiotensin II is associated with activation of NF-kappaB-mediated genes and downregulation of PPARs.血管紧张素II与NF-κB介导的基因激活及过氧化物酶体增殖物激活受体（PPARs）的下调有关。
Physiol Genomics. 2002 Oct 2;11(1):21-30. doi: 10.1152/physiolgenomics.00062.2002.
5
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol.氯沙坦干预降低高血压终点事件研究（LIFE）中的心血管发病率和死亡率：一项与阿替洛尔对比的随机试验。
Lancet. 2002 Mar 23;359(9311):995-1003. doi: 10.1016/S0140-6736(02)08089-3.
6
Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury.血管紧张素II 2型受体刺激联合缬沙坦选择性阻断血管紧张素II 1型受体在改善炎症诱导的血管损伤中的作用。
Circulation. 2001 Nov 27;104(22):2716-21. doi: 10.1161/hc4601.099404.
7
Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells.Rho激酶介导血管紧张素II诱导的大鼠血管平滑肌细胞单核细胞趋化蛋白-1表达。
Hypertension. 2001 Jul;38(1):100-4. doi: 10.1161/01.hyp.38.1.100.
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Monocyte chemoattractant protein-1 and macrophage infiltration in hypertensive kidney injury.单核细胞趋化蛋白-1与巨噬细胞浸润在高血压肾损伤中的作用
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Monocyte chemoattractant protein-1 is upregulated in rats with volume-overload congestive heart failure.
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