Singh Kumud K, Barroga Charlene F, Hughes Michael D, Chen Jie, Raskino Claire, McKinney Ross E, Spector Stephen A
Department of Pediatrics, Division of Infectious Diseases, University of California at San Diego, La Jolla 92093-0672, USA.
J Acquir Immune Defic Syndr. 2004 Mar 1;35(3):309-13. doi: 10.1097/00126334-200403010-00013.
Several chemokines and chemokine receptors are involved in HIV-1 infection, disease progression, and transmission. We studied the prevalence of genetic variations in CCR2, SDF1, and the CCR5 gene and its promoter region at positions 59029, 59353, and 59356 in a seroprevalent cohort of 1057 children with symptomatic HIV-1 infection in the United States. The percentage of children with the CCR5-wt/Delta32 genotype was significantly higher for white, non-Hispanic children (15%) than for Hispanic (6%) or black, non-Hispanic children (4%). For the CCR5-59029-G/A, CCR5-59353-T/C, and CCR5-59356-C/T polymorphisms, there were significant or marginally significant differences in genotype frequencies across race/ethnicity groups. For the CCR2-wt/64I polymorphism, both black, non-Hispanic and Hispanic children had a higher frequency of the CCR2-wt/64I genotype (24% and 21%, respectively) and CCR2-64I/64I genotype (4% and 3%, respectively) than white, non-Hispanic children (14% and 2%, respectively). For the SDF1-3'-G/A polymorphism, black, non-Hispanic children had a lower combined frequency of the SDF1-3'-G/A and SDF1-3'-A/A genotypes (15%) than did Hispanic children (33%) and white, non-Hispanic children (37%). These analyses show that the distribution of chemokine receptor and chemokine genetic polymorphisms varies significantly across race/ethnicity subgroups of HIV-1-infected children in the United States.
几种趋化因子和趋化因子受体参与了HIV-1感染、疾病进展及传播过程。我们在美国一个有症状的HIV-1感染儿童血清流行队列（共1057名儿童）中，研究了CCR2、SDF1以及CCR5基因及其启动子区域在59029、59353和59356位点的基因变异流行情况。CCR5-wt/Delta32基因型儿童的比例，非西班牙裔白人儿童（15%）显著高于西班牙裔儿童（6%）或非西班牙裔黑人儿童（4%）。对于CCR5-59029-G/A、CCR5-59353-T/C和CCR5-59356-C/T多态性，不同种族/族裔组的基因型频率存在显著或边缘显著差异。对于CCR2-wt/64I多态性，非西班牙裔黑人和西班牙裔儿童的CCR2-wt/64I基因型频率（分别为24%和21%）以及CCR2-64I/64I基因型频率（分别为4%和 3%）均高于非西班牙裔白人儿童（分别为14%和2%）。对于SDF1-3'-G/A多态性，非西班牙裔黑人儿童的SDF1-3'-G/A和SDF1-3'-A/A基因型合并频率（15%）低于西班牙裔儿童（33%）和非西班牙裔白人儿童（37%）。这些分析表明，在美国感染HIV-1儿童的不同种族/族裔亚组中，趋化因子受体和趋化因子基因多态性的分布存在显著差异。
