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严重大流行（H1N1）2009 患者的趋化因子受体 5 △32 等位基因。

Chemokine receptor 5 △32 allele in patients with severe pandemic (H1N1) 2009.

机构信息

Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

出版信息

Emerg Infect Dis. 2010 Oct;16(10):1621-2. doi: 10.3201/eid1610.100108.

DOI:10.3201/eid1610.100108
PMID:20875295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3294998/
Abstract

Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Δ32 allele than were members of the general population. We found a large proportion of heterozygosity for the CCR5Δ32 allele among white patients with severe disease.

摘要

由于趋化因子受体 5（CCR5）可能在肺部免疫反应中发挥作用，我们探讨了重症大流行（H1N1）2009 流感病毒患者是否比一般人群更有可能携带 CCR5Δ32 等位基因。我们发现，患有严重疾病的白人患者中 CCR5Δ32 等位基因的杂合率较高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3590/3294998/dfb6f2dde97f/10-0108-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3590/3294998/dfb6f2dde97f/10-0108-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3590/3294998/dfb6f2dde97f/10-0108-F.jpg

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