Mirza Yousha, Tang Jennifer, Russell Aileen, Banerjee S Preeya, Bhandari Rashmi, Ivey Jennifer, Rose Michelle, Moore Gregory J, Rosenberg David R
Department of Psychiatry, Wayne State University, Detroit, MI 48201, USA.
J Am Acad Child Adolesc Psychiatry. 2004 Mar;43(3):341-8. doi: 10.1097/00004583-200403000-00017.
To examine in vivo glutamatergic neurochemical alterations in the anterior cingulate cortex of children with major depressive disorder (MDD).
Single-voxel proton magnetic resonance spectroscopic (H-MRS) examinations of the anterior cingulate cortex were conducted in 13 psychotropic-naïve children and adolescents with MDD and 13 age- and sex-matched healthy children and adolescents. Ten of the 13 MDD patient-control pairs also had a H-MRS examination of occipital cortex.
Anterior cingulate glutamatergic (Glx) concentrations were significantly lower (19% decrease) in MDD patients versus controls (9.27 +/- 0.43 versus 11.47 +/- 0.26, respectively, p = 0.000). Reduced anterior cingulate Glx in MDD patients was associated with increased severity of functional impairment. These results remained comparably significant after controlling for age and anterior cingulate volume. Occipital cortex Glx did not differ between MDD patients and controls.
These preliminary findings provide new evidence of localized functional neurochemical marker alterations in Glx in anterior cingulate cortex in pediatric MDD. Altered anterior cingulate Glx neurotransmission may be involved in the pathogenesis of MDD.
研究重度抑郁症（MDD）患儿前扣带回皮质内谷氨酸能神经化学变化。
对13例未服用过精神药物的MDD儿童和青少年以及13例年龄和性别匹配的健康儿童和青少年进行前扣带回皮质的单体素质子磁共振波谱（H-MRS）检查。13对MDD患者-对照中，有10对还进行了枕叶皮质的H-MRS检查。
与对照组相比，MDD患者前扣带回谷氨酸能（Glx）浓度显著降低（降低19%）（分别为9.27±0.43和11.47±0.26，p = 0.000）。MDD患者前扣带回Glx降低与功能损害严重程度增加有关。在控制年龄和前扣带回体积后，这些结果仍然具有相当的显著性。MDD患者和对照组的枕叶皮质Glx无差异。
这些初步研究结果为小儿MDD前扣带回皮质中Glx的局部功能性神经化学标志物改变提供了新证据。前扣带回Glx神经传递改变可能参与了MDD的发病机制。
