儿童重度抑郁症患者前扣带回谷氨酸水平降低：一项磁共振波谱研究
Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study.
作者信息
Rosenberg David R, Macmaster Frank P, Mirza Yousha, Smith Janet M, Easter Phillip C, Banerjee S Preeya, Bhandari Rashmi, Boyd Courtney, Lynch Michelle, Rose Michelle, Ivey Jennifer, Villafuerte Rosemond A, Moore Gregory J, Renshaw Perry
机构信息
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
出版信息
Biol Psychiatry. 2005 Nov 1;58(9):700-4. doi: 10.1016/j.biopsych.2005.05.007. Epub 2005 Aug 8.
BACKGROUND
Anterior cingulate cortex has been implicated in the pathogenesis of major depressive disorder (MDD). With single voxel proton magnetic resonance spectroscopy, we reported reductions in anterior cingulate glutamatergic concentrations (grouped value of glutamate and glutamine) in 14 pediatric MDD patients versus 14 case-matched healthy control subjects. These changes might reflect a change in glutamate, glutamine, or their combination.
METHODS
Fitting to individually quantify anterior cingulate glutamate and glutamine was performed in these subjects with a new basis set created from data acquired on a 1.5 Tesla General Electric Signa (GE Healthcare, Waukesha, Wisconsin) magnetic resonance imaging scanner with LCModel (Version 6.1-0; Max-Planck-Institute, Gottingen, Germany).
RESULTS
Reduced anterior cingulate glutamate was observed in MDD patients versus control subjects (8.79 +/- 1.68 vs. 11.46 +/- 1.55, respectively, p = .0002; 23% decrease). Anterior cingulate glutamine did not differ significantly between patients with MDD and control subjects.
CONCLUSIONS
These findings provide confirmatory evidence of anterior cingulate glutamate alterations in pediatric MDD.
背景
前扣带回皮质与重度抑郁症（MDD）的发病机制有关。我们通过单体素质子磁共振波谱分析发现，14例儿科MDD患者与14例年龄匹配的健康对照者相比，前扣带回谷氨酸能浓度（谷氨酸和谷氨酰胺的组合值）降低。这些变化可能反映了谷氨酸、谷氨酰胺或它们组合的改变。
方法
使用在1.5特斯拉通用电气Signa（GE医疗集团，威斯康星州沃基沙）磁共振成像扫描仪上采集的数据创建的新基集，通过LCModel（版本6.1-0；德国哥廷根马克斯-普朗克研究所）对这些受试者进行拟合，以单独量化前扣带回的谷氨酸和谷氨酰胺。
结果
与对照者相比，MDD患者前扣带回谷氨酸水平降低（分别为8.79±1.68和11.46±1.55，p = 0.0002；降低23%）。MDD患者与对照者之间前扣带回谷氨酰胺水平无显著差异。
结论
这些发现为儿科MDD患者前扣带回谷氨酸改变提供了确证性证据。
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