Kim D H, Hyun S H, Shim S B, Kobashi K
Department of Microbiology, College of Pharmacy, Kyung-Hee University, Seoul, Korea.
Jpn J Pharmacol. 1992 May;59(1):1-5. doi: 10.1254/jjp.59.1.
Sodium picosulfate, a laxative, was biotransformed to 4,4'-dihydroxydiphenyl-(2 pyridyl)-methane by intestinal flora that produced a novel sulfotransferase (not sulfatase). The biotransformation was activated by adding phenolic compounds such as phenol, acetaminophen and flavonoids. The enzyme activity related to this biotransformation was the highest in the contents of the caecum region of the intestine. The enzyme activity was 3.0 mumole/hr/g wet feces in humans and 0.75 in rats (pH 8.0). The optimal pH was 9.0.
比沙可啶是一种泻药，经肠道菌群生物转化为4,4'-二羟基二苯基-（2-吡啶基）-甲烷，该肠道菌群产生了一种新型磺基转移酶（而非硫酸酯酶）。添加酚类化合物如苯酚、对乙酰氨基酚和类黄酮可激活这种生物转化。与这种生物转化相关的酶活性在肠道盲肠区域内容物中最高。该酶活性在人类粪便湿重中为3.0微摩尔/小时/克，在大鼠中为0.75微摩尔/小时/克（pH 8.0）。最适pH为9.0。
