Starzl Thomas E, Murase Noriko, Demetris Anthony J, Trucco Massimo, Abu-Elmagd Kareem, Gray Edward A, Eghtesad Bijan, Shapiro Ron, Marcos Amadeo, Fung John J
Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Transplantation. 2004 Mar 27;77(6):926-9. doi: 10.1097/01.tp.0000117780.74133.74.
Although the reductionist approach has served science well for 400 years, the accumulation of details can obscure the truth if the original premise is incorrect. One such premise has been that successful organ transplantation and bone marrow engraftment are fundamentally different outcomes involving separate and distinct mechanisms. Some historical clinical observations pointed to a different conclusion almost from the beginning and included clues about how to induce tolerance with the aid of immunosuppression.
尽管还原论方法在400年来一直对科学起到很好的作用，但如果最初的前提不正确，细节的积累可能会掩盖真相。其中一个这样的前提是，成功的器官移植和骨髓移植是本质上不同的结果，涉及不同且独特的机制。一些历史临床观察几乎从一开始就指向了不同的结论，其中包括关于如何借助免疫抑制诱导免疫耐受的线索。
