Chao Nelson J
Department of Medicine and Immunology, Durham, North Carolina 27710, USA.
Biol Blood Marrow Transplant. 2004 Apr;10(4):215-23. doi: 10.1016/j.bbmt.2003.10.003.
Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation. These miHA are peptide fragments that are associated with major histocompatibility complex class I or class II antigens. Elegant experiments have led to the molecular characterization of these antigens. Efforts to prevent graft-versus-host disease could be targeted through this pathway by matching for these miHA or by preventing antigen recognition. Alternatively, these miHA could be exploited as targets for a more potent graft-versus-malignancy effect. This area of miHA promises to continue to be an exciting area of continued research.
微小组织相容性抗原（miHA）在主要组织相容性复合体匹配的同胞异基因干细胞移植中，是导致移植物抗宿主病发生的原因。这些miHA是与主要组织相容性复合体I类或II类抗原相关的肽片段。精细的实验已实现了对这些抗原的分子特征描述。通过匹配这些miHA或阻止抗原识别，可针对这一途径来预防移植物抗宿主病。或者，这些miHA可被用作产生更强移植物抗肿瘤效应的靶点。miHA这一领域有望继续成为一个令人兴奋的持续研究领域。
