Elliott Jessica, Koldej Rachel, Khot Amit, Ritchie David
ACRF Translational Research Laboratory, Royal Melbourne Hospital, Melbourne, VIC, Australia.
Department of Clinical Haematology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Methods Mol Biol. 2025;2907:1-56. doi: 10.1007/978-1-0716-4430-0_1.
A variety of graft-versus-host disease (GVHD) models have been developed in mice for the purpose of allowing laboratory investigation of the pathobiology, prevention, and treatment of GVHD in humans. While such models are crucial in advancing our knowledge in this field, there are some key limitations that need to be considered when translating laboratory discoveries into the clinical context. This chapter will discuss current clinical practices in transplantation and GVHD and the relative strengths and weaknesses of mouse models that attempt to replicate these states.
为了能够在实验室中研究人类移植物抗宿主病（GVHD）的病理生物学、预防和治疗，已经在小鼠中建立了多种GVHD模型。虽然这些模型对于推动我们在该领域的知识发展至关重要，但在将实验室发现转化为临床实际应用时，需要考虑一些关键的局限性。本章将讨论移植和GVHD的当前临床实践，以及试图复制这些状态的小鼠模型的相对优缺点。
