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1983 - 2001年期间,重度类风湿关节炎临床表现的住院率下降情况。

Decreases in rates of hospitalizations for manifestations of severe rheumatoid arthritis, 1983-2001.

作者信息

Ward Michael M

机构信息

National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-1828, USA.

出版信息

Arthritis Rheum. 2004 Apr;50(4):1122-31. doi: 10.1002/art.20158.

Abstract

OBJECTIVE

To determine whether the rates of hospitalization for 4 manifestations of severe rheumatoid arthritis (RA), which are used as indicators of long-term health outcomes, have changed from 1983 to 2001.

METHODS

Data on all patients with RA who were hospitalized with rheumatoid vasculitis or to undergo splenectomy for Felty's syndrome, cervical spine fusion for myelopathy, or total knee arthroplasty at hospitals in California were abstracted from a state hospitalization database. Changes in rates of hospitalization from 1983 to 2001 were examined in this serial cross-sectional study.

RESULTS

Rates of hospitalization for rheumatoid vasculitis and splenectomy in Felty's syndrome decreased progressively over time. The risk of hospitalization for rheumatoid vasculitis was one-third lower in 1998-2001 than in 1983-1987. The risk of hospitalization for splenectomy in Felty's syndrome was 71% lower in 1998-2001 than in 1983-1987. There were no significant decreases in the rates of hospitalization for cervical spine surgery or total knee arthroplasty (primary and revision), although in 1998-2001 there was a reversal of the trend of increasing rates of total knee arthroplasty. The risk of hospitalization for primary total knee arthroplasty was significantly lower in 1998-2001 than in 1990-1993 (rate ratio 0.90, 95% confidence interval 0.86-0.95; P < 0.0001).

CONCLUSION

Rates of hospitalization for rheumatoid vasculitis and splenectomy in Felty's syndrome have decreased over the past 19 years, and there has been a recent decrease in the rates of primary total knee arthroplasty in patients with RA. Although several factors may account for these decreases, these findings suggest that since the early 1980s, the long-term health outcomes of patients with RA have improved.

摘要

目的

确定作为严重类风湿关节炎(RA)长期健康结局指标的4种表现形式的住院率在1983年至2001年期间是否发生了变化。

方法

从加利福尼亚州的医院住院数据库中提取了所有因类风湿性血管炎住院、因费尔蒂综合征接受脾切除术、因脊髓病接受颈椎融合术或全膝关节置换术的RA患者的数据。在这项系列横断面研究中,对1983年至2001年的住院率变化进行了检查。

结果

类风湿性血管炎和费尔蒂综合征脾切除术的住院率随时间逐渐下降。1998 - 2001年类风湿性血管炎的住院风险比1983 - 1987年降低了三分之一。1998 - 2001年费尔蒂综合征脾切除术的住院风险比1983 - 1987年降低了71%。颈椎手术或全膝关节置换术(初次和翻修)的住院率没有显著下降,尽管在1998 - 2001年全膝关节置换术的增加率趋势出现了逆转。1998 - 2001年初次全膝关节置换术的住院风险显著低于1990 - 1993年(率比0.90,95%置信区间0.86 - 0.95;P < 0.0001)。

结论

在过去19年中,类风湿性血管炎和费尔蒂综合征脾切除术的住院率有所下降,RA患者初次全膝关节置换术的发生率近期也有所下降。尽管有几个因素可能解释这些下降,但这些发现表明自20世纪80年代初以来,RA患者的长期健康结局有所改善。

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