Barkagan Z S, Serdiuk G V, Golubenko V N
Klin Med (Mosk). 1992 Feb;70(2):42-4.
The paper described the appearance of lipoid anticoagulant (LA) in the presence of hepatitis B virus in the blood of hemophilia A patient. Profuse and long-term bleeding after the extraction of the tooth that failed to be treated with big doses of cryoprecipitation was noted. Intense replacement therapy resulted in the appearance of factor VIII inhibitor in a titre of 4.5 units per ml in the patient's blood. Big-dose prednisolone therapy helped an immediate arrest of the bleeding and a rapid decrease in LA titration. The levels of factor VIII inhibitor preserved in the same values. The study exhibited the ability of LA to impede the arrest of the bleeding and the response to the replacement treatment in hemophilic patients.
该论文描述了甲型血友病患者血液中存在乙型肝炎病毒时类脂抗凝剂（LA）的表现。注意到拔牙后出现大量且长期出血，大剂量冷沉淀治疗无效。强化替代治疗导致患者血液中出现凝血因子VIII抑制剂，滴度为每毫升4.5单位。大剂量泼尼松龙治疗有助于立即止血，并使LA滴定迅速下降。凝血因子VIII抑制剂水平保持在相同值。该研究显示了LA阻碍血友病患者止血及对替代治疗反应的能力。
