Hortells Aznar J L, Ibáñez Estella J A, Pérez de Viñaspre Adrados S, Atance Martínez J C, Larraz Mur L, Lasierra Díaz M P
Servicio de Medicina Interna, Hospital Clínico Universitario, Zaragoza.
Med Clin (Barc). 1992 Jun 27;99(5):172-4.
Fibronectin is a protein with opsonic capacity. Its plasma level is diminished in septic shock. The aim of the present was to study its behavior in other types of shock.
A prospective study of 60 patients in shock (septic, hypovolemic and cardiogenic) was carried out. Serial plasma levels of fibronectin were determined in these patients over a period of 72 hours. The values of the cases which evolved favorably were compared with the values of those which did not.
In all the cases, the plasma levels of fibronectin were diminished within a minimum of approximately 12 hours with a tendency to recovery of initial values being observed within 72 hours, except in cases in which the evolution of the patient was poor. In these cases fibronectin values remained diminished in such statistical significant.
Plasma levels of fibronectin behave similarly in the three types of shock studied (septic, hypovolemic and cardiogenic). Serial determination of fibronectin provides a good prognostic index in patients with shock.
纤连蛋白是一种具有调理作用的蛋白质。其血浆水平在感染性休克中会降低。本研究的目的是探讨其在其他类型休克中的表现。
对60例休克患者（感染性、低血容量性和心源性）进行了一项前瞻性研究。在72小时内测定这些患者的纤连蛋白系列血浆水平。将病情好转患者的值与未好转患者的值进行比较。
在所有病例中，纤连蛋白的血浆水平至少在约12小时内降低，除患者病情恶化的情况外，在72小时内观察到有恢复初始值的趋势。在这些病例中，纤连蛋白值仍显著降低。
在所研究的三种休克类型（感染性、低血容量性和心源性）中，纤连蛋白的血浆水平表现相似。对纤连蛋白进行系列测定可为休克患者提供良好的预后指标。
