Avradopoulos Vasiliki, Wilder Rebecca S, Chichester Stacy, Offenbacher Steve
Graduate Dental Hygiene Education Program, University of North Carolina, Chapel Hill School of Dentistry, USA.
J Dent Hyg. 2004 Winter;78(1):30-8.
The purpose of this pilot study was to evaluate the clinical and inflammatory changes produced in chronic, non-responsive periodontitis sites when comparing traditional scaling and root planing with scaling and root-planning using Perioscopy The sample size consisted of six patients who exhibited chronic periodontitis after completing initial therapy and under going periodontal maintenance for at least one year. The study was a within patient match site design. In which each patient had six to eight periodontal pockets measuring 5 mm to 8 mm. Half of the sites in each patients mouth were treated with scaling and root planing only (control group) and the other half of the sites were treated with scaling and root planing plus Perioscopy (experimental group). At one month evaluations, 50% of the control sites had a decrease of > 2 mm (11 out of 22 sites) and 55% of the experimental sites had a decrease in pocket depth of > 2 mm (12 out of 22 sites). When comparisons were made between baseline and three month evaluations of total pocket depths, 55% of the control sites had a decrease of > 2 mm (10 out of 22 sites). Chi-Square statistical analysis at one and three month evaluations showed non-significant decreases in pocket depth among control sites and experimental sites (p = 0.76, p = 0.55). At baseline, IL-1 mean levels and control sites were 43.47 pg/ml and 37.29 pg/ml for experimental for one month evaluation. II-1_mean levels were 33.03 pg/ml for control sites and 32.29 pg/ml for experimental sites. At the three month evaluation. IL-1 mean levels were 15.33 pg/ml for control sites and 14.42 pg/ml for experimental sites. Statistical t-test analysis assuming unequal variances at baseline, months one and three showed non-significant trends between control and experimental sites (p = 0.27, p = 0.47, p = 0.45). At baseline, PGE2, levels were 18.85 pg/ml for the control group abd 24,013 pg/ml for experimental sites. At one moth, PGE2 levels were 15.16 pg/ml for control sites and 16.23 pg/ml for experimental sites. At the three month evaluation, PGE2 levels were 14.18 pg/ml for the control sites and 15.92 pg/ml for the experimental group. T-test analysis of unequal variance showed non-significant trends in the data at baseline, one and three months for PGE2 (p = 0.26, p = 0.40, p = 0.31). The intent of this pilot study was to compare the changes in periodontal pocket depths and inflammatory markers of the control (scaling and root planing) and experimental (scaling and root planing with Perioscopy) sites. Analysis revealed no statistically significant differences in clinical and inflammatory analysis of the control sites and experimental sites though the three month evaluation period. Further studies are needed to determine the effectiveness of Perioscopy with a longer evaluation period.
本初步研究的目的是，比较传统的龈下刮治术和根面平整术与使用牙周内窥镜的龈下刮治术和根面平整术，评估慢性、无反应性牙周炎部位产生的临床和炎症变化。样本量包括六名患者，他们在完成初始治疗并接受至少一年的牙周维护后，表现出慢性牙周炎。该研究采用患者自身对照位点设计。其中，每名患者有6至8个深度为5毫米至8毫米的牙周袋。每名患者口腔中一半的位点仅接受龈下刮治术和根面平整术（对照组），另一半位点接受龈下刮治术、根面平整术加牙周内窥镜治疗（实验组）。在1个月的评估中，50%的对照位点袋深减少>2毫米（22个位点中的11个），55%的实验位点袋深减少>2毫米（22个位点中的12个）。当比较基线和3个月评估时的总袋深时，55%的对照位点袋深减少>2毫米（22个位点中的10个）。在1个月和3个月评估时的卡方统计分析显示，对照位点和实验位点的袋深减少无显著差异（p = 0.76，p = 0.55）。在基线时，1个月评估的对照组IL-1平均水平为43.47 pg/ml，实验组为37.29 pg/ml。3个月评估时，对照组IL-1平均水平为33.03 pg/ml，实验组为32.29 pg/ml。在基线、1个月和3个月时，假设方差不等的统计t检验分析显示，对照位点和实验位点之间无显著趋势（p = 0.27，p = 0.47，p = 0.45）。在基线时，对照组PGE2水平为18.85 pg/ml，实验组为24,013 pg/ml。在1个月时，对照位点PGE2水平为15.16 pg/ml，实验位点为16.23 pg/ml。在3个月评估时，对照位点PGE2水平为14.18 pg/ml，实验组为15.92 pg/ml。方差不等的t检验分析显示，基线、1个月和3个月时PGE2数据无显著趋势（p = 0.26，p = 0.40，p = 0.31）。本初步研究的目的是比较对照（龈下刮治术和根面平整术）和实验（使用牙周内窥镜的龈下刮治术和根面平整术）位点的牙周袋深度变化和炎症标志物。分析显示，在3个月的评估期内，对照位点和实验位点的临床和炎症分析无统计学显著差异。需要进一步研究以确定更长评估期内牙周内窥镜的有效性。
