Pfeffer M A, Ferrell B A, Pfeffer J M, Weiss A K, Fishbein M C, Frohlich E D
Am J Physiol. 1978 Aug;235(2):H193-9. doi: 10.1152/ajpheart.1978.235.2.H193.
Spontaneously hypertensive rats (SHR) and two strains of normotensive Wistar rats were subjected to a 5 day/wk swimming program to determine whether the heart of the SHR could respond to an additional stimulus to cardiac growth. Swimming was tolerated well by all rats. Although body weight of the exercised groups was not significantly reduced, both the right and left ventricular weights of all exercised groups were increased. Left ventricular circumference and chamber volume were increased without a change in free wall thickness in all exercised groups. Ventricular performance was assessed by peak cardiac output and stroke volume attained during rapid intravenous volume loading, both before and after autonomic inhibition. After combined cholinergic and beta-adrenergic inhibition, all exercised rats had slower heart rates and higher peak stroke volume than respectively sedentary controls. Thus, exercised SHR had the same alterations in cardiac mass and performance as exercised normotensive rats. Despite the initial presence of left ventricular hypertrophy, the SHR responded appropriately to an additional stimulus for adaptive cardiac growth.
将自发性高血压大鼠（SHR）和两株正常血压的Wistar大鼠进行每周5天的游泳训练，以确定SHR的心脏是否能对额外的心脏生长刺激做出反应。所有大鼠对游泳耐受良好。尽管运动组的体重没有显著减轻，但所有运动组的右心室和左心室重量均增加。所有运动组的左心室周长和腔室容积增加，而游离壁厚度没有变化。通过自主抑制前后快速静脉容量负荷期间达到的峰值心输出量和每搏输出量来评估心室功能。在胆碱能和β-肾上腺素能联合抑制后，所有运动大鼠的心率均较慢，峰值每搏输出量均高于相应的久坐对照组。因此，运动的SHR与运动的正常血压大鼠在心脏质量和功能方面有相同的变化。尽管最初存在左心室肥厚，但SHR对额外的适应性心脏生长刺激有适当反应。
