Petrović Zeljko
Institut za otorinolaringologiju i maksilofacijalnu hirurgiju, Klinicki centar Srbije, Beograd.
Med Pregl. 2003 Nov-Dec;56(11-12):568-70. doi: 10.2298/mpns0312568p.
Supraglottis is a part of larynx comprising two subregions: epilarynx (suprahyoid epiglottis--including lingual and laryngeal surface, aryepiglottic folds--laryngeal surface, and arytenoids) and supraglottis without epilarynx (infrahyioid epiglottis and ventricular folds).
A total of 234 patients with supraglottic squamous cell carcinoma undergoing primary surgery were analyzed in the period 1976-1996. The tumor was localized in epilarynx in 84 (25%) patients, and in supraglottis without epilarynx in 261 (75%) cases.
T1 tumor was present in 145 (42%) patients, T2 tumor was found in 178 (52%) patients, while T3 was reported in 22 (6%) cases. Clinically negative neck (N0) was found in 290 (84%) patients, and palpable metastases (N1) manifested in 55 (16%) cases. Local recurrences were established in 18 (5%) patients, and subsequent postoperative cervical metastases were found in 45 (13%) cases. Five-year disease-free survival was reported in 76% (262/345) of patients. Nasogastric tubes were removed in all patients approximately 12 days following surgery. 27 patients developed laryngeal stenosis and only 2 patients were not decannulated. Voice and speech functions were satisfactory.
Supraglottic laryngectomy, extended supraglottic laryngectomy is fully justified from oncological and functional aspects. Selective neck dissection in N0 cervical findings provides detection of occult metastases and indicates need for postoperative radiotherapy.
Oncological and functional results of supraglottic laryngeal surgery, along with simultaneous treatment of neck by selective, modified radical neck dissection and postoperative radiotherapy offer hope for treatment of supraglottic laryngeal cancer.
声门上区是喉的一部分,由两个亚区域组成:喉上部(舌骨上会厌——包括舌面和喉面、杓会厌襞——喉面以及杓状软骨)和声门上区的非喉上部(舌骨下会厌和室襞)。
对1976年至1996年期间接受初次手术的234例声门上区鳞状细胞癌患者进行了分析。肿瘤位于喉上部的有84例(25%)患者,位于声门上区的非喉上部的有261例(75%)。
145例(42%)患者为T1期肿瘤,178例(52%)患者为T2期肿瘤,22例(6%)患者为T3期肿瘤。290例(84%)患者临床颈部阴性(N0),55例(16%)患者出现可触及的转移灶(N1)。18例(5%)患者出现局部复发,45例(13%)患者术后出现颈部转移。76%(262/345)的患者报告了5年无病生存率。所有患者术后约12天拔除鼻胃管。27例患者出现喉狭窄,只有2例患者未拔管。语音和言语功能良好。
从肿瘤学和功能方面来看,声门上喉切除术、扩大声门上喉切除术是完全合理的。对于N0颈部检查结果进行选择性颈清扫可发现隐匿性转移灶,并提示术后放疗的必要性。
声门上喉手术的肿瘤学和功能结果,以及通过选择性改良根治性颈清扫和术后放疗同时治疗颈部,为声门上喉癌的治疗带来了希望。