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2001年捷克共和国的血清学调查——百日咳

The 2001 serological survey in the Czech Republic--pertussis.

作者信息

Maixnerová M

机构信息

National Reference Laboratory for Pertussis and Parapertussis, Charles University in Prague, 3rd Medical Faculty, Prague, Czech Republic.

出版信息

Cent Eur J Public Health. 2003 Dec;11 Suppl:S17-22.

PMID:15080254
Abstract

The results of the 2001 serological survey show that the immunity status of 2-year old children has improved (89.7% seropositive) after the modification of the vaccination schedule while the immunity status for one-year-olds remains poor (57.6% seropositive). The highest prevalence of seropositivity was seen in the age categories from 12 to 44 years (90-97%). The increasing values of seropositivity and relatively higher titers of antibodies (in particular against type 1,3 of B. pertussis) in older children and adolescents likely reflect an ongoing infection in this population.

摘要

2001年血清学调查结果显示,在调整疫苗接种计划后,2岁儿童的免疫状况有所改善(血清阳性率为89.7%),而1岁儿童的免疫状况仍然较差(血清阳性率为57.6%)。血清阳性率最高的年龄段为12至44岁(90%-97%)。年龄较大的儿童和青少年血清阳性率不断上升,且抗体滴度相对较高(尤其是针对百日咳杆菌1型、3型),这可能反映出该人群中存在持续感染。

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Infect Dis Ther. 2021 Dec;10(4):2071-2118. doi: 10.1007/s40121-021-00520-9. Epub 2021 Aug 26.
2
Bordetella pertussis infection or vaccination substantially protects mice against B. bronchiseptica infection.百日咳博德特氏菌感染或疫苗接种可显著保护小鼠免受支气管败血波氏杆菌感染。
PLoS One. 2009 Aug 26;4(8):e6778. doi: 10.1371/journal.pone.0006778.
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The O antigen enables Bordetella parapertussis to avoid Bordetella pertussis-induced immunity.
O抗原使副百日咳博德特氏菌能够逃避百日咳博德特氏菌诱导的免疫反应。
Infect Immun. 2007 Oct;75(10):4972-9. doi: 10.1128/IAI.00763-07. Epub 2007 Aug 13.