Heimer G M, Englund D E
Department of Obstetrics and Gynaecology, Uppsala University, Akademiska sjukhuset, Sweden.
Maturitas. 1992 Mar;14(3):171-9. doi: 10.1016/0378-5122(92)90112-h.
Forty post-menopausal women with urogenital disorders who were inpatients in the same geriatric hospital were treated with oestriol (E3) for 6 weeks. For the first 2 weeks 0.5 mg E3 (Leo AB, Sweden) was administered intravaginally every day. Over the following 4 weeks the patients received the same quantity either once or twice weekly as a maintenance dose. Oestrogen influence on the vaginal and urethral epithelium was assessed by means of the karyopyknotic index (KPI), while the degree of maturation of the vaginal epithelium was estimated visually. Urinary bacteria were cultivated. A pronounced and progressive rise in KPI was seen in both the vaginal and the urethral epithelium following daily E3 treatment. However, neither of the two maintenance dosages was sufficient to sustain the initial maturation of the vaginal and urethral epithelium induced by E3, since the KPI returned to pretreatment values within 4 weeks. The effect of E3 administration on the vaginal epithelium was overestimated by the visual assessment method. No changes were seen in urinary bacteria. Medroxyprogesterone acetate was given before and after E3 treatment. None of the women suffered from withdrawal bleeding.
40名患有泌尿生殖系统疾病的绝经后女性在同一家老年医院住院，接受了6周的雌三醇（E3）治疗。在最初的2周内，每天经阴道给予0.5mg E3（瑞典Leo AB公司生产）。在接下来的4周内，患者每周接受相同剂量一次或两次作为维持剂量。通过核固缩指数（KPI）评估雌激素对阴道和尿道上皮的影响，同时通过肉眼估计阴道上皮的成熟程度。培养尿液细菌。每日给予E3治疗后，阴道和尿道上皮的KPI均出现显著且渐进性升高。然而，两种维持剂量均不足以维持E3诱导的阴道和尿道上皮的初始成熟，因为KPI在4周内恢复到治疗前值。视觉评估方法高估了E3给药对阴道上皮的影响。尿液细菌未见变化。在E3治疗前后给予醋酸甲羟孕酮。所有女性均未出现撤药性出血。
