Puzanowska-Tarasiewicz Helena, Karpińska Joanna
Institute of Chemistry, University of Białystok, 1 Hurtowa Str., 15-339 Białystok, Poland.
Acta Pol Pharm. 2003 Nov-Dec;60(6):409-15.
The run and analytical application of oxidation reaction of promazine (PM) and thioridazine (TR) hydrochlorides with iron(III) and ferrocyanide(III) are described. The coloured products of oxidation absorb at 512 nm for promazine and 634 nm for thioridazine. This property is a basis of a rapid, accurate and sensitive spectrophotometric method for determination of these phenothiazines. The elaborated methods allow to determine 3-28 microgPM/ml in Fe(III)-PM and 2-11 microgPM/ml in Fe(CN)6-PM systems, 2.5-22 microgTR/ml in the Fe(III)-TR and 4-16 microgTR/ml in Fe(CN)6-TR systems.
