γ-五味子乙素的高效合成。
Efficient synthesis of gamma-DDB.
作者信息
Chang Junbiao, Guo Xiaohe, Cheng Senxiang, Guo Ruiyun, Chen Rongfeng, Zhao Kang
机构信息
Chemistry Department, University of Science and Technology of China, Hefei, PR China.
出版信息
Bioorg Med Chem Lett. 2004 May 3;14(9):2131-6. doi: 10.1016/j.bmcl.2004.02.055.
PMID:15080994
Abstract
Synthesis of gamma-DDB, which is another family member of gamma-DDB (dimethyl 4,4(')-dimethoxy-5,6,5('),6(')- dimethylenedioxybiphenyl-2,2(')-dicarboxylate), is described. The unsymmetric isomer (gamma-DDB) was constructed by a linker-directed intramolecular Ullmann coupling reaction, followed by the cleavage of the linker and re-esterification.
摘要
描述了γ-DDB（4,4'-二甲氧基-5,6,5',6'-二亚甲基二氧基联苯-2,2'-二羧酸二甲酯，γ-DDB家族的另一个成员）的合成。通过连接基导向的分子内乌尔曼偶联反应构建不对称异构体（γ-DDB），随后裂解连接基并进行重新酯化。
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