Chang Junbiao, Guo Xiaohe, Cheng Senxiang, Guo Ruiyun, Chen Rongfeng, Zhao Kang
Chemistry Department, University of Science and Technology of China, Hefei, PR China.
Bioorg Med Chem Lett. 2004 May 3;14(9):2131-6. doi: 10.1016/j.bmcl.2004.02.055.
Synthesis of gamma-DDB, which is another family member of gamma-DDB (dimethyl 4,4(')-dimethoxy-5,6,5('),6(')- dimethylenedioxybiphenyl-2,2(')-dicarboxylate), is described. The unsymmetric isomer (gamma-DDB) was constructed by a linker-directed intramolecular Ullmann coupling reaction, followed by the cleavage of the linker and re-esterification.
描述了γ-DDB（4,4'-二甲氧基-5,6,5',6'-二亚甲基二氧基联苯-2,2'-二羧酸二甲酯，γ-DDB家族的另一个成员）的合成。通过连接基导向的分子内乌尔曼偶联反应构建不对称异构体（γ-DDB），随后裂解连接基并进行重新酯化。
