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Reversing effect of dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) on the phenotypes of human hepatocarcinoma cells line.

作者信息

Liu Z, Liu G, Zhang S

机构信息

Department of Pharmacology, Chinese Academy of Medical Sciences, Peking Union Medical University, Beijing, PR China.

出版信息

Cancer Lett. 1996 Nov 12;108(1):67-72. doi: 10.1016/s0304-3835(96)04389-3.

DOI:10.1016/s0304-3835(96)04389-3
PMID:8950211
Abstract

When human Bel-7402 hepatocarcinoma cell line grew in a medium containing 10(-4) M dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylenedioxybiphynyl-2,2'-dicarboxylate (DDB), the secretion of alpha-fetoprotein (AFP) was significantly lower than the control cells, whereas the albumin (ALB) secretion was markedly higher. The activity of gamma-glutamultranspepeidase (gamma-GT) in DDB-treated cells markedly decreased in comparison with the control cells. On the contrary, the activity of tyrosine-alpha-ketoglutarate transaminase (TAT) was higher in DDB-treated cells than in control cells. DDB (10(-4) M) could significantly increase the content of cAMP in Bel-7402 cells, and also enhance the expression of anti-oncogene p53. The results suggest that DDB has reversing effects on the phenotypes of the human Bel-7402 hepatocarcinoma cell line.

摘要

相似文献

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引用本文的文献

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Possible carcinogenic potential of dimethyl dimethoxy biphenyl dicarboxylate in experimental animals.二甲基二甲氧基联苯二羧酸酯在实验动物中的潜在致癌性。
J Adv Pharm Technol Res. 2016 Apr-Jun;7(2):54-8. doi: 10.4103/2231-4040.179747.
2
The anti-hepatitis drug DDB chemosensitizes multidrug resistant cancer cells in vitro and in vivo by inhibiting P-gp and enhancing apoptosis.抗肝炎药物联苯双酯通过抑制P-糖蛋白和增强凋亡作用，在体外和体内使多药耐药癌细胞对化疗药物敏感。
Invest New Drugs. 2007 Apr;25(2):95-105. doi: 10.1007/s10637-006-9001-z.
3
The promoting molecular mechanism of alpha-fetoprotein on the growth of human hepatoma Bel7402 cell line.
甲胎蛋白对人肝癌Bel7402细胞系生长的促进分子机制
World J Gastroenterol. 2002 Jun;8(3):469-75. doi: 10.3748/wjg.v8.i3.469.