不同剂型中某些硫醇化合物的差分电解电位测定法。

Differential electrolytic potentiometric determination of some thiol compounds in their dosage forms.

作者信息

Al-Ghannam S M

机构信息

Department of Chemistry, Girls College of Science, P.O. Box 838, Dammam 31113, Saudi Arabia.

出版信息

Farmaco. 2004 Apr;59(4):331-4. doi: 10.1016/j.farmac.2003.12.004.

DOI:10.1016/j.farmac.2003.12.004

PMID:15081351

Abstract

The application of direct current differential electrolytic potentiometry to an aqueous titration of L-cysteine hydrochloride, captopril and D-penicillamine has been investigated. The basic character of thiol compounds in nitric acid is enhanced to permit their direct titrations with silver nitrate. A pair of silver amalgam electrodes was used as an indicating system. Titration curve shapes obtained are almost symmetrical with sharp peaks. The optimum current density for those titrations was found to be 0.2-2 microA/cm2. The procedure was applied successfully to the determination of certain thiol compounds in drug formulations and the results were favorably compared statistically with those obtained from official methods.

摘要

研究了直流差示电解电位法在盐酸L-半胱氨酸、卡托普利和D-青霉胺水相滴定中的应用。硫醇化合物在硝酸中的碱性增强，从而可以用硝酸银直接滴定它们。使用一对银汞电极作为指示系统。得到的滴定曲线形状几乎对称，有尖锐的峰。发现这些滴定的最佳电流密度为0.2 - 2微安/平方厘米。该方法成功应用于药物制剂中某些硫醇化合物的测定，结果经统计学分析与官方方法所得结果相比具有优势。