Chemistry Department, King Fahd University of Petroleum and Minerals, KFUPM, P.O. Box 1726, Dhahran 31261, Saudi Arabia.
Talanta. 2003 Oct 17;61(2):239-44. doi: 10.1016/S0039-9140(03)00246-7.
A simple and rapid differential electrolytic potentiometric titration method for the determination of ciprofloxacin was developed. The work is based on the fast complexation reaction between iron(III) and ciprofloxacin in a ratio of 1:3, respectively, in sulfuric acid media of 0.09 mol dm(-3). Among the electrodes tested silver amalgam electrodes were found to be a suitable indicating system. By applying a current density of 0.5 muA cm(-2) to these electrodes and using iron(III) solution of 0.097 mol dm(-3) as a titrant, normal titration curves were obtained. The method was successfully applied for the determination of ciprofloxacin in drug formulations as low as 4.0 ppm.
建立了一种简单快速的差示电解电位滴定法，用于测定环丙沙星。该工作基于在硫酸介质（0.09 mol dm(-3)）中，铁(III)与环丙沙星以 1:3 的比例快速络合反应。在所测试的电极中，发现银汞齐电极是一种合适的指示系统。通过向这些电极施加 0.5 μA cm(-2)的电流密度，并使用 0.097 mol dm(-3)的铁(III)溶液作为滴定剂，得到了正常的滴定曲线。该方法成功地应用于药物制剂中环丙沙星低至 4.0 ppm 的测定。
