Tomie Arthur, Uveges Jillian M, Burger Kelly M, Patterson-Buckendahl Patricia, Pohorecky Larissa A
Department of Psychology and Center of Alcohol Studies, Rutgers University, New Brunswick, NJ 08903, USA.
Alcohol Alcohol. 2004 May-Jun;39(3):197-202. doi: 10.1093/alcalc/agh055.
The present study evaluates the effects of pairing ethanol sipper conditioned stimulus (CS) with social opportunity unconditioned stimulus (US) on CS-directed ethanol drinking in rats. Subjects were Long-Evans male rats (n = 32) deprived of neither food nor water, and the concentration of unsweetened ethanol (3 to 16%) in the sipper CS was increased across sessions.
Group Paired/Ethanol (n = 12) received the ethanol sipper CS for 10 s immediately prior to 15 s of social opportunity US. Control groups received water rather than ethanol in the sipper CS (Paired/Water), or ethanol sipper CS and US presentations randomly (Random/Ethanol), or ethanol sipper CS but no social opportunity US (Sipper Only).
Mean ethanol intake in the Paired/Ethanol and Random/Ethanol groups exceeded 1.0 g/kg when the sipper CS contained 12%, 14% and 16% ethanol, and higher fluid intakes were observed in the Paired/Ethanol and Random/Ethanol groups than in the Paired/Water and Sipper Only groups.
Social opportunity increased ethanol drinking, and more so than water drinking; however, autoshaping did not induce additional ethanol drinking beyond that observed in random controls.
本研究评估将乙醇吸管条件刺激(CS)与社交机会非条件刺激(US)配对对大鼠中针对CS的乙醇饮用量的影响。实验对象为Long-Evans雄性大鼠(n = 32),未剥夺食物和水,且在各实验阶段中,吸管CS中未加糖乙醇的浓度(3%至16%)逐渐增加。
配对/乙醇组(n = 12)在15秒社交机会非条件刺激之前立即接受10秒乙醇吸管条件刺激。对照组在吸管CS中接受的是水而非乙醇(配对/水组),或者乙醇吸管条件刺激和非条件刺激随机呈现(随机/乙醇组),或者只接受乙醇吸管条件刺激但无社交机会非条件刺激(仅吸管组)。
当吸管CS中含有12%、14%和16%乙醇时,配对/乙醇组和随机/乙醇组的平均乙醇摄入量超过1.0克/千克,且配对/乙醇组和随机/乙醇组的液体摄入量高于配对/水组和仅吸管组。
社交机会增加了乙醇饮用量,且比水饮用量增加得更多;然而,自动形成条件反射并未导致超出随机对照组观察到的额外乙醇饮用量。