Prachumwat Anuphap, DeVincentis Laura, Palopoli Michael F
Department of Biology, Bowdoin College, Brunswick, Maine 04011, USA.
Genetics. 2004 Mar;166(3):1585-90. doi: 10.1534/genetics.166.3.1585.
A negative correlation between intron size and recombination rate has been reported for the Drosophila melanogaster and human genomes. Population-genetic models suggest that this pattern could be caused by an interaction between recombination rate and the efficacy of natural selection. To test this idea, we examined variation in intron size and recombination rate across the genome of the nematode Caenorhabditis elegans. Interestingly, we found that intron size correlated positively with recombination rate in this species.
据报道，在黑腹果蝇和人类基因组中，内含子大小与重组率之间存在负相关。群体遗传学模型表明，这种模式可能是由重组率与自然选择效力之间的相互作用导致的。为了验证这一观点，我们研究了秀丽隐杆线虫基因组中内含子大小和重组率的变化。有趣的是，我们发现该物种的内含子大小与重组率呈正相关。
