Vavricka S R, Halter J, Hechelhammer L, Himmelmann A
Department of Medicine, University Hospital of Zurich, Switzerland.
Postgrad Med J. 2004 Apr;80(942):236-8. doi: 10.1136/pgmj.2003.012252.
Pneumocystis carinii pneumonia in patients with chronic lymphocytic leukaemia (CLL) who have not been treated with fludarabin are rare, although clinically relevant CD4 T-cell depletion can occur in longstanding CLL without prior treatment with purine analogues. A 52 year old woman is reported who was on long term treatment with chlorambucil and taking a short course of prednisone for familial CLL before she developed progressive dyspnoea, and P carinii pneumonia was diagnosed in bronchoalveolar lavage fluid. Despite treatment with high dose co-trimoxazole the patient died.
未接受氟达拉滨治疗的慢性淋巴细胞白血病（CLL）患者发生卡氏肺孢子虫肺炎较为罕见，尽管在未经嘌呤类似物治疗的长期CLL患者中可能出现具有临床意义的CD4 T细胞耗竭。本文报道了一名52岁女性，她长期接受苯丁酸氮芥治疗，因家族性CLL服用短期泼尼松，之后出现进行性呼吸困难，支气管肺泡灌洗液中诊断出卡氏肺孢子虫肺炎。尽管接受了高剂量复方新诺明治疗，患者仍死亡。
