Sung Chang Okh, Ko Young Hyeh
Department of Pathology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea.
J Korean Med Sci. 2004 Apr;19(2):229-33. doi: 10.3346/jkms.2004.19.2.229.
To evaluate the frequency of bone marrow involvement by nasal-type NK/T cell lymphoma, we retrospectively studied biopsy specimens from 40 patients by EBV in situ hybridization (ISH). Three patients had marrow involvement at initial diagnosis (7.5%). In one patient (1/40, 2.5%), the disease in bone marrow was recognized by routine morphological assessment, while two other patients had minimal involvement of lymphoma cells which was recognized only by EBV in situ hybridization (2/40, 5%). Two patients had a disseminated disease at diagnosis and died 6 days and 214 days after diagnosis. One patient had diffuse colonic lesion and died 82 days later. In conclusion, marrow involvement in nasal NK/T cell lymphoma is infrequent at initial diagnosis, and EBV ISH is a useful technique for identifying the minor subgroup of patients which have easily overlooked neoplastic involvement.
为评估鼻型NK/T细胞淋巴瘤骨髓受累的频率，我们通过EBV原位杂交（ISH）对40例患者的活检标本进行了回顾性研究。3例患者在初诊时出现骨髓受累（7.5%）。1例患者（1/40，2.5%）通过常规形态学评估诊断出骨髓疾病，而另外2例患者仅有少量淋巴瘤细胞受累，仅通过EBV原位杂交才能识别（2/40，5%）。2例患者在诊断时已有播散性疾病，分别在诊断后6天和214天死亡。1例患者有弥漫性结肠病变，82天后死亡。总之，鼻型NK/T细胞淋巴瘤初诊时骨髓受累并不常见，EBV原位杂交是识别易被忽视的肿瘤受累患者小亚组的有用技术。
