Bae Sung Hwa, Ryoo Hun Mo, Cho Hee Soon, Lee Jae Lyun, Lee Kyung Hee, Hyun Myung Soo
Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, Korea.
J Korean Med Sci. 2004 Apr;19(2):311-4. doi: 10.3346/jkms.2004.19.2.311.
The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months later, he complained of a mild headache. The results of the physical examination and the complete blood counts were normal. The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy.
中枢神经系统受累在急性早幼粒细胞白血病（APL）中较为罕见。我们报告了一名41岁的韩国男性APL患者，该患者出现发热和瘀点。通过全反式维甲酸（ATRA）、伊达比星和阿糖胞苷实现了完全分子缓解。十个月后，他主诉轻度头痛。体格检查和全血细胞计数结果正常。脑脊液检查显示存在早幼粒细胞。骨髓研究显示细胞遗传学缓解但有分子复发。他接受了鞘内和全身化疗。
