Pacilli Leonardo, Lo Coco Francesco, Ramadan Safaa Mahmoud, Giannì Laura, Pingi Alberto, Remotti Daniele, Majolino Ignazio
Hematology and BMT Unit, Institute of Hematotherapy, Ospedale S. Camillo, 00153 Rome, Italy.
Adv Hematol. 2010;2010:137608. doi: 10.1155/2010/137608. Epub 2010 Mar 18.
Myeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremely uncommon in acute promyelocytic leukemia (APL). In the case described here, MS was the sole site of APL relapse and the cause of spinal cord compression. The patient presented with neurologic symptoms due to a paravertebral mass of MS after 7 years of complete remission. He was treated with excision of the mass followed by local radiotherapy. Systemic treatment was also given with combined arsenic trioxide and all-trans retinoic acid and the patient was able to achieve a second prolonged clinical and molecular remission.
髓系肉瘤（MS，以前称为粒细胞肉瘤或绿色瘤）是一种罕见的未成熟髓系细胞的髓外肿瘤。它可在急性髓系白血病诊断之前、同时或之后出现。MS在急性早幼粒细胞白血病（APL）中极为罕见。在本文所述病例中，MS是APL复发的唯一部位及脊髓压迫的原因。该患者在完全缓解7年后，因椎旁MS肿块出现神经症状。他接受了肿块切除及局部放疗治疗。还给予了三氧化二砷和全反式维甲酸联合全身治疗，患者得以实现第二次长期临床和分子缓解。
