Powles T, Bower M, Shamash J, Stebbing J, Ong J, Daugaard G, De Ruiter A, Johnson M, Fisher M, Anderson J, Nelson M, Gazzard B, Oliver T
Department of Oncology, Chelsea and Westminster Hospital, Fulham Road, London SW10 9NH, UK.
Br J Cancer. 2004 Apr 19;90(8):1526-30. doi: 10.1038/sj.bjc.6601762.
Testicular germ cell tumour (GCT) is not an AIDS-defining illness despite an increased incidence in men with HIV infection. We performed a matched case-control study comparing outcomes in HIV-positive men and the general population with GCT, using three age and stage matched controls for each case. There was no difference in the 5-year GCT-free survival between cases and controls. However, overall survival was significantly decreased in the cases (log rank P=0.03). HIV was responsible for 70% of this mortality. The relapse-free survival for stage I patients treated with orchidectomy and surveillance was not affected by HIV status (log rank P=0.68). There was no difference in disease free survival in patients with metastatic disease (log rank P=0.78). The overall survival has not improved since the introduction of highly active antiretroviral therapy (log rank P=0.4). Thus, HIV-related GCT is not more aggressive than GCT in the general population.
睾丸生殖细胞肿瘤（GCT）并非艾滋病定义疾病，尽管HIV感染男性的发病率有所上升。我们进行了一项匹配病例对照研究，比较HIV阳性男性和患有GCT的普通人群的预后，每个病例使用三个年龄和分期匹配的对照。病例组和对照组的5年无GCT生存率没有差异。然而，病例组的总生存率显著降低（对数秩检验P = 0.03）。HIV导致了70%的死亡率。接受睾丸切除术和监测的I期患者的无复发生存率不受HIV状态影响（对数秩检验P = 0.68）。转移性疾病患者的无病生存率没有差异（对数秩检验P = 0.78）。自引入高效抗逆转录病毒治疗以来，总生存率没有改善（对数秩检验P = 0.4）。因此，与HIV相关的GCT并不比普通人群中的GCT更具侵袭性。
