Musto P, Vinay P, Coalda M, Bono D, Vai G
Servizio di Anestesia e Rianimazione, Ospedale SS. Annunziata, USSL 61, Savigliano, Cuneo.
Minerva Anestesiol. 1992 Jul-Aug;58(7-8):459-64.
Neuroleptic malignant syndrome (NMS) in its most severe form ranging from disorders of consciousness to coma is now reported relatively frequently in intensive care journals. Having observed such a case in the intensive care ward of their hospital, the Authors investigate the possibility of differential diagnosis between this syndrome and other prevalently psychiatric and non-psychiatric types. It is underlined that the diagnosis of NMS is not straightforward taking into account both the type of patients who are mainly affected, that is to say psychopathic subjects undergoing prolonged therapy with heavy tranquillisers, in poor general condition, sometimes abandoned and then found in coma, and the fact that some psychiatric syndromes or drug overdoses may led to similar symptoms but require completely different treatment.
神经阻滞剂恶性综合征(NMS)最严重的形式包括从意识障碍到昏迷,目前在重症监护期刊中报道相对频繁。作者在他们医院的重症监护病房观察到这样一例病例后,研究了该综合征与其他主要为精神性和非精神性类型疾病进行鉴别诊断的可能性。需要强调的是,考虑到主要受影响的患者类型,即正在接受大剂量镇静剂长期治疗、一般状况较差、有时被遗弃然后昏迷的精神病患者,以及一些精神综合征或药物过量可能导致类似症状但需要完全不同治疗这一事实,NMS的诊断并非简单直接。