Carroll Linda J, Cassidy J David, Peloso Paul M, Borg Jörgen, von Holst Hans, Holm Lena, Paniak Chris, Pépin Michel
Alberta Centre for Injury Control and Research, Department of Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada.
J Rehabil Med. 2004 Feb(43 Suppl):84-105. doi: 10.1080/16501960410023859.
We searched the literature on the epidemiology, diagnosis, prognosis, treatment and costs of mild traumatic brain injury. Of 428 studies related to prognosis after mild traumatic brain injury, 120 (28%) were accepted after critical review. These comprise our best-evidence synthesis on prognosis after mild traumatic brain injury. There was consistent and methodologically sound evidence that children's prognosis after mild traumatic brain injury is good, with quick resolution of symptoms and little evidence of residual cognitive, behavioural or academic deficits. For adults, cognitive deficits and symptoms are common in the acute stage, and the majority of studies report recovery for most within 3-12 months. Where symptoms persist, compensation/litigation is a factor, but there is little consistent evidence for other predictors. The literature on this area is of varying quality and causal inferences are often mistakenly drawn from cross-sectional studies.
我们检索了有关轻度创伤性脑损伤的流行病学、诊断、预后、治疗及成本的文献。在428项与轻度创伤性脑损伤后预后相关的研究中，经严格评审后，120项（28%）被纳入。这些构成了我们关于轻度创伤性脑损伤后预后的最佳证据综合。有一致且方法合理的证据表明，儿童轻度创伤性脑损伤后的预后良好，症状能迅速缓解，几乎没有残留认知、行为或学业缺陷的迹象。对于成年人，认知缺陷和症状在急性期很常见，大多数研究报告称大多数人在3至12个月内恢复。若症状持续存在，赔偿/诉讼是一个因素，但几乎没有其他预测因素的一致证据。该领域的文献质量参差不齐，因果推断往往错误地从横断面研究中得出。
