Hui Alan, Marraffa Jeanna M, Stork Christine M
Central New York Poison Control Center, Department of Emergency Medicine, University Hospital, SUNY Upstate Medical University, Syracuse, New York, USA.
J Toxicol Clin Toxicol. 2004;42(1):93-5. doi: 10.1081/clt-120028752.
The Black Locust (Robinia Pseudoacacia) tree contain toxalbumins, robin and phasin, that exert their toxic effects by inhibition of protein synthesis. Despite the potential dangers of Black Locust intoxication, reports of human toxicity after ingestion are rare. We report the first human intoxication of Black Locust bark in North America in over one hundred years.
An eight-year-old male was brought to the emergency department 6 hours after chewing and expelling the Black Locust bark. He presented with emesis, which began approximately 2.5 hours after exposure. His vital signs were as follows: oral temperature, 97.5 degrees F; blood pressure, 128/75 mmHg; heart rate, 114 beats per minute; respiratory rate, 15 breaths per minute. Initial treatment included 4 mg i.v. ondansetron, which resolved the vomiting, one dose of activated charcoal, and intravenous fluids. He was then admitted to the intensive care unit (ICU) for observation of signs of toxicity. Laboratory findings were unremarkable except for a white blood cell of 18.4 K/uL and an elevated alkaline phosphatase of 183 U/L. The patient remained asymptomatic throughout his stay in the ICU and was discharged on the fifth day of admission with a normal white blood cell of 4.1 K/uL and an alkaline phosphatase of 251 U/L.
Patients with clinical toxicity following the ingestion of Black Locust are expected to do well with supportive care and observation.
刺槐（Robinia Pseudoacacia）树含有毒蛋白、刺槐蛋白和植酸蛋白，它们通过抑制蛋白质合成发挥毒性作用。尽管刺槐中毒存在潜在危险，但摄入后人类中毒的报告却很少见。我们报告了北美一百多年来首例刺槐树皮中毒事件。
一名8岁男性在咀嚼并吐出刺槐树皮6小时后被送往急诊科。他出现呕吐，在接触后约2.5小时开始。他的生命体征如下：口腔温度97.5华氏度；血压128/75毫米汞柱；心率114次/分钟；呼吸频率15次/分钟。初始治疗包括静脉注射4毫克昂丹司琼，这缓解了呕吐，一剂活性炭和静脉输液。然后他被收入重症监护病房（ICU）观察中毒迹象。实验室检查结果无异常，除了白细胞计数为18.4K/μL和碱性磷酸酶升高至183U/L。患者在ICU住院期间一直无症状，入院第五天出院，白细胞计数正常为4.1K/μL，碱性磷酸酶为251U/L。
摄入刺槐后出现临床中毒的患者通过支持性护理和观察有望恢复良好。
