Mitchell G S, Sloan H E, Jiang C, Miletic V, Hayashi F, Lipski J
Department of Comparative Biosciences, University of Wisconsin, Madison 53706.
Neurosci Lett. 1992 Jul 6;141(1):75-8. doi: 10.1016/0304-3940(92)90338-8.
Experiments on anesthetized, spinalized rats were conducted to determine the effects of systemic 5-hydroxytryptophan (5-HTP) administration on: (1) spontaneous phrenic nerve activity and (2) evoked phrenic responses to short latency, non-serotonergic synaptic inputs elicited by electrical stimulation of lateral funiculus. 5-HTP augmented spontaneous phrenic activity and allowed expression of a second, longer latency evoked response. Both effects were antagonized by methysergide. Our results suggest that spinal serotonin increases the efficacy of synaptic inputs to phrenic motoneurons.
对麻醉且脊髓横断的大鼠进行实验，以确定全身性给予5-羟色氨酸（5-HTP）对以下方面的影响：（1）膈神经自发放电活动，以及（2）膈神经对由电刺激外侧索引发的短潜伏期非5-羟色胺能突触输入的诱发反应。5-HTP增强了膈神经自发放电活动，并使第二个潜伏期更长的诱发反应得以表达。这两种效应均被麦角酰二乙胺（methysergide）拮抗。我们的结果表明，脊髓5-羟色胺可提高膈运动神经元突触输入的效能。
