Yamane Takashi, Maruyama Osamu, Nishida Masahiro, Toyoda Masahiro, Tsutsui Tatsuo, Jikuya Tomoaki, Shigeta Osamu, Sankai Yoshiyuki
National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.
Artif Organs. 2004 Apr;28(4):390-7. doi: 10.1111/j.1525-1594.2004.47110.x.
The purpose of this study was to eliminate fluid dynamic causes of thrombus formation for the monopivot magnetic suspension centrifugal pump under development with the aid of flow visualization as an indirect measurement tool for animal experiments. The formation of thrombus observed in early animal experiments was successfully overcome by combining the multiple washout holes at the center into a single hole, optimizing the hole diameter, and eliminating the pivot gap. Flow visualization was used to optimize the washout hole diameter influencing the flow around the pivot. In animal experiments flow visualization showed that the contours of thrombus corresponded to shear rates of 300 s(-1) or 1300-1700 s(-1). It was found that flow visualization is a useful technique to predict locations where low shear thrombi form and to optimize the pump design in the development stage.
本研究的目的是借助流动可视化这一用于动物实验的间接测量工具，消除正在研发的单轴磁悬浮离心泵中血栓形成的流体动力学原因。通过将中心处的多个冲洗孔合并为一个孔、优化孔径并消除枢轴间隙，成功克服了早期动物实验中观察到的血栓形成问题。流动可视化被用于优化影响枢轴周围流动的冲洗孔直径。在动物实验中，流动可视化显示血栓轮廓对应于300 s⁻¹或1300 - 1700 s⁻¹的剪切率。结果发现，流动可视化是一种有用的技术，可用于预测低剪切血栓形成的位置，并在研发阶段优化泵的设计。
