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DAX-1在人类乳腺癌中的表达：与雌激素受体ER-α、ER-β及雄激素受体状态的比较

DAX-1 expression in human breast cancer: comparison with estrogen receptors ER-alpha, ER-beta and androgen receptor status.

作者信息

Conde Isabel, Alfaro Juan M, Fraile Benito, Ruíz Antonio, Paniagua Ricardo, Arenas Maria I

机构信息

Department of Cell Biology and Genetics, University of Alcalá, Alcalá de Henares, Madrid, Spain.

出版信息

Breast Cancer Res. 2004;6(3):R140-8. doi: 10.1186/bcr766. Epub 2004 Feb 13.

DOI:10.1186/bcr766
PMID:15084237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC400665/
Abstract

BACKGROUND

So far there have been no reports on the expression pattern of DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) in human breast cells and its relationship to the estrogen receptors, ER-alpha and ER-beta, and the androgen receptor (AR).

METHODS

In this study we evaluated, by immunohistochemistry and Western blot analysis, the presence and distribution of DAX-1 in benign breast disease (BBD), in situ carcinoma (CIS), and ductal and lobular breast carcinomas.

RESULTS

In BBD and breast carcinomas, DAX-1 was present in both the nuclei and the cytoplasm of epithelial cells, although in infiltrative carcinomas the percentage of nuclear immunoreaction was higher than in CIS. An important relation was observed between DAX-1 and AR expression and between this orphan receptor and nodal status.

CONCLUSION

DAX-1 might modify the AR and ER-beta intracellular location, and because a direct positive relation between the expression of these three receptors was found it could be assumed that the presence of DAX-1 in neoplastic cells might indicate a possible failure of endocrine therapies.

摘要

背景

迄今为止，尚无关于DAX - 1（X染色体剂量敏感性性反转、肾上腺发育不全关键区域基因1）在人乳腺细胞中的表达模式及其与雌激素受体ER - α和ER - β以及雄激素受体（AR）关系的报道。

方法

在本研究中，我们通过免疫组织化学和蛋白质印迹分析评估了DAX - 1在良性乳腺疾病（BBD）、原位癌（CIS）以及乳腺导管癌和小叶癌中的存在情况及分布。

结果

在BBD和乳腺癌中，DAX - 1存在于上皮细胞的细胞核和细胞质中，尽管在浸润性癌中核免疫反应的百分比高于原位癌。观察到DAX - 1与AR表达之间以及该孤儿受体与淋巴结状态之间存在重要关系。

结论

DAX - 1可能会改变AR和ER - β的细胞内定位，并且由于发现这三种受体的表达之间存在直接正相关关系，因此可以推测肿瘤细胞中DAX - 1的存在可能表明内分泌治疗可能失败。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ea/400665/62640fdba412/bcr766-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ea/400665/9e6fc03e090b/bcr766-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ea/400665/77c34b96a374/bcr766-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ea/400665/62640fdba412/bcr766-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ea/400665/9e6fc03e090b/bcr766-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ea/400665/77c34b96a374/bcr766-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23ea/400665/62640fdba412/bcr766-3.jpg

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