Allegra J C, Lippman M E, Thompson E B, Simon R, Barlock A, Green L, Huff K K, Do H M, Aitken S C
Cancer Res. 1979 May;39(5):1447-54.
The distribution and frequency of steroid hormone receptors are described 329 patients with breast cancer. The distribution of each of the steroid hormone receptors is unimodal with a progressive increase in the proportion of patients positive at lower receptor values. Receptor values expressed as fmol/mg cytoplasmic protein are well correlated with values expressed as fmol/mg breast tumor. Estrogen receptor was positive in 53% of the patients; progesterone receptor was positive in 38% of the patients; glucocorticoid receptor was positive in 52% of the patients; and androgen receptor was positive in 31% of the patients. The type of tissue assayed did not affect steroid hormone receptor positivity. For primary tumors, there was no correlation between steroid hormone receptor positivity and location of the tumor in the breast, size of the tumor, or extent of the disease. Each of the steroid hormone receptors was positively associated with each of the other steroid hormone receptors. Estrogen receptor was correlated with menopausal status and axillary nodal status, but these correlations did not exist for the other steroid hormone receptors. Estrogen receptor was not correlated with age after adjustment for menopausal status. The other steroid hormone receptors were not correlated with age.
本文描述了329例乳腺癌患者甾体激素受体的分布及频率。每种甾体激素受体的分布均为单峰型，受体值较低时阳性患者比例逐渐增加。以每毫克细胞质蛋白中所含飞摩尔数表示的受体值，与以每毫克乳腺肿瘤中所含飞摩尔数表示的值密切相关。53%的患者雌激素受体呈阳性；38%的患者孕激素受体呈阳性；52%的患者糖皮质激素受体呈阳性；31%的患者雄激素受体呈阳性。所检测的组织类型不影响甾体激素受体的阳性率。对于原发性肿瘤，甾体激素受体阳性与肿瘤在乳腺中的位置、肿瘤大小或疾病范围之间无相关性。每种甾体激素受体均与其他甾体激素受体呈正相关。雌激素受体与绝经状态及腋窝淋巴结状态相关，但其他甾体激素受体不存在此类相关性。校正绝经状态后，雌激素受体与年龄无关。其他甾体激素受体与年龄无关。
