引发自身免疫：NOD小鼠
Driven to autoimmunity: the nod mouse.
作者信息
Gallegos Alena M, Bevan Michael J
机构信息
Howard Hughes Medical Institute and the Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA.
出版信息
Cell. 2004 Apr 16;117(2):149-51. doi: 10.1016/s0092-8674(04)00340-x.
Abstract
In the lymphoid system, T cells respond to space or under-crowding by dividing to maintain their numbers. In this issue of Cell, evidence is provided that this homeostatic proliferation, coupled with excess production of a cytokine, IL-21, is a key factor in susceptibility to autoimmune diabetes.
摘要
在淋巴系统中，T细胞通过分裂来维持自身数量，以应对空间或细胞密度不足的情况。在本期《细胞》杂志中，有证据表明这种稳态增殖，再加上一种细胞因子IL-21的过量产生，是易患自身免疫性糖尿病的关键因素。
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