Yuhki Munehiro, Yamada Masahisa, Kawano Masako, Iwasato Takuji, Itohara Shigeyoshi, Yoshida Hisahiro, Ogawa Masaharu, Mishina Yuji
Laboratory for Cell Culture Development, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
Development. 2004 Apr;131(8):1825-33. doi: 10.1242/dev.01079. Epub 2004 Mar 17.
Interactions between ectodermal and mesenchymal extracellular signaling pathways regulate hair follicle (HF) morphogenesis and hair cycling. Bone morphogenetic proteins (BMPs) are known to be important in hair follicle development by affecting the local cell fate modulation. To study the role of BMP signaling in the HF, we disrupted Bmpr1a, which encodes the BMP receptor type IA (BMPR1A) in an HF cell-specific manner, using the Cre/loxP system. We found that the differentiation of inner root sheath, but not outer root sheath, was severely impaired in mutant mice. The number of HFs was reduced in the dermis and subcutaneous tissue, and cycling epithelial cells were reduced in mutant mice HFs. Our results strongly suggest that BMPR1A signaling is essential for inner root sheath differentiation and is indispensable for HF renewal in adult skin.
外胚层和间充质细胞外信号通路之间的相互作用调节毛囊（HF）形态发生和毛发周期。已知骨形态发生蛋白（BMP）通过影响局部细胞命运调控在毛囊发育中起重要作用。为了研究BMP信号在毛囊中的作用，我们利用Cre/loxP系统以毛囊细胞特异性方式破坏了编码IA型BMP受体（BMPR1A）的Bmpr1a。我们发现，突变小鼠的内根鞘而非外根鞘的分化严重受损。真皮和皮下组织中的毛囊数量减少，突变小鼠毛囊中的循环上皮细胞减少。我们的结果强烈表明，BMPR1A信号对于内根鞘分化至关重要，并且对于成年皮肤中的毛囊更新不可或缺。
