Chaturvedi R R, Macrae D, Brown K L, Schindler M, Smith E C, Davis K B, Cohen G, Tsang V, Elliott M, de Leval M, Gallivan S, Goldman A P
Randall Centre, King's College, London, UK.
Heart. 2004 May;90(5):545-51. doi: 10.1136/hrt.2002.003509.
To delineate predictors of hospital survival in a large series of children with biventricular physiology supported with extracorporeal membrane oxygenation (ECMO) after open heart surgery.
81 children were placed on ECMO after open heart surgery. 58% (47 of 81) were transferred directly from cardiopulmonary bypass to ECMO. Hospital survival was 49% (40 of 81) but there were seven late deaths among these survivors (18%). Factors that improved the odds of survival were initiation of ECMO in theatre (64% survival (30 of 47)) rather than the cardiac intensive care unit (29% survival (10 of 34)) and initiation of ECMO for reactive pulmonary hypertension. Important adverse factors for hospital survival were serious mechanical ECMO circuit problems, renal support, residual lesions, and duration of ECMO.
Hospital survival of children with biventricular physiology who require cardiac ECMO is similar to that found in series that include univentricular hearts, suggesting that successful cardiac ECMO is critically dependent on the identification of hearts with reversible ventricular dysfunction. In our experience of postoperative cardiac ECMO, the higher survival of patients cannulated in the operating room than in the cardiac intensive care unit is due to early effective support preventing prolonged hypoperfusion and the avoidance of a catastrophic cardiac arrest.
明确大量接受心脏直视手术后采用体外膜肺氧合(ECMO)支持的双心室生理患儿的院内生存预测因素。
81例患儿在心脏直视手术后接受了ECMO治疗。58%(81例中的47例)直接从体外循环转至ECMO。院内生存率为49%(81例中的40例),但这些幸存者中有7例晚期死亡(18%)。提高生存几率的因素包括在手术室启动ECMO(生存率64%(47例中的30例))而非在心脏重症监护病房启动(生存率29%(34例中的10例))以及因反应性肺动脉高压启动ECMO。院内生存的重要不利因素包括严重的ECMO机械回路问题、肾脏支持、残余病变和ECMO持续时间。
需要心脏ECMO支持的双心室生理患儿的院内生存率与包括单心室心脏的系列研究结果相似,这表明成功的心脏ECMO关键取决于识别具有可逆性心室功能障碍的心脏。根据我们术后心脏ECMO的经验,在手术室插管患者的生存率高于心脏重症监护病房,这是因为早期有效支持可防止长时间低灌注并避免灾难性心脏骤停。