Høgh Peter, Madsen Sjö Nina, Gade Anders, Waldemar Gunhild
Memory Disorders Research Unit, The Neuroscience Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Dement Geriatr Cogn Disord. 2004;18(1):15-23. doi: 10.1159/000077730. Epub 2004 Apr 6.
Single photon emission computer tomography (SPECT) applied early in the course of Alzheimer's disease (AD) may identify regions with impaired brain function. Moreover, it may be relevant to characterize SPECT perfusion patterns in patients with mild cognitive impairment (MCI), in particular the subgroup of MCI patients with isolated amnesia, as these patients have been demonstrated to convert to AD in more than half of the cases within 3 years. The primary aim of the present study was to characterize the regional cerebral blood flow (CBF) in patients with neuropsychologically verified isolated amnesia. We examined 32 patients (11 men/21 women) with isolated amnesia according to strict neuropsychological criteria and 15 healthy volunteers (11 men/4 women). All subjects had an SPECT-99mTc-d,l-HMPAO perfusion study and neuropsychological assessments. Cranial MRI or CT was performed in all subjects. Semiquantitative (cerebellar relative) flow values were calculated and statistically compared. Patients with isolated amnesia had significant hypoperfusion in several cortical regions of interest compared to control subjects, most prominently in the left temporal cortex. Additionally, there was a trend towards globally reduced CBF in the patients, although this was not significant. These findings may indicate the presence of a progressive degenerative illness affecting multiple brain regions at its early or preclinical stage.
在阿尔茨海默病（AD）病程早期应用单光子发射计算机断层扫描（SPECT）可能识别出脑功能受损区域。此外，对轻度认知障碍（MCI）患者，特别是孤立性遗忘的MCI患者亚组的SPECT灌注模式进行特征描述可能具有重要意义，因为这些患者已被证明在3年内超过半数会转化为AD。本研究的主要目的是对经神经心理学验证的孤立性遗忘患者的局部脑血流量（CBF）进行特征描述。我们根据严格的神经心理学标准检查了32例孤立性遗忘患者（11例男性/21例女性）和15名健康志愿者（11例男性/4例女性）。所有受试者均进行了SPECT - 99mTc - d，l - HMPAO灌注研究和神经心理学评估。所有受试者均进行了头颅MRI或CT检查。计算半定量（小脑相对）血流值并进行统计学比较。与对照受试者相比，孤立性遗忘患者在几个感兴趣的皮质区域存在明显的灌注不足，最显著的是左侧颞叶皮质。此外，患者的CBF有整体降低的趋势，尽管不显著。这些发现可能表明在疾病的早期或临床前期存在一种影响多个脑区的进行性退行性疾病。
