Kim Kyu-Rae, Park Kyoung-Hee, Kim Jung-Won, Cho Kyoung-Ja, Ro Jae Y
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Int J Gynecol Pathol. 2004 Apr;23(2):182-7. doi: 10.1097/00004347-200404000-00015.
A case of extensive transitional cell metaplasia (TCM) and ectopic prostatic tissue was encountered in the uterine cervix and vagina of a 23-year-old woman with the adrenogenital syndrome. A previously described case of ectopic prostatic tissue in the cervix in a patient with female pseudohermaphroditism and our case suggest that prolonged androgen stimulation plays a role in the development of prostatic tissue. Similarly, the occurrence of TCM in the perimenopausal and postmenopausal periods when the ovaries secrete androgens, in female transsexuals treated with androgens, and in our patient with high endogenous androgen levels suggest that androgen has a major role in the histogenesis of TCM. Significantly decreased Ki-67 immunopositivity in TCM compared with the normal cervical mucosa of women in the reproductive age indicates that TCM is a mild form of epithelial atrophy, presumably caused by the neutralizing effect of androgens.
在一名患有肾上腺生殖器综合征的23岁女性的子宫颈和阴道中，发现了一例广泛的移行细胞化生（TCM）和异位前列腺组织。先前描述的一例女性假两性畸形患者宫颈中出现异位前列腺组织的病例以及我们的病例表明，长期雄激素刺激在前列腺组织的发育中起作用。同样，在卵巢分泌雄激素的围绝经期和绝经后期、接受雄激素治疗的女性易性病患者以及我们这位内源性雄激素水平高的患者中出现TCM，表明雄激素在TCM的组织发生中起主要作用。与育龄期女性的正常宫颈黏膜相比，TCM中Ki-67免疫阳性显著降低，这表明TCM是上皮萎缩的一种轻度形式，可能是由雄激素的中和作用引起的。
