Suda Koichi, Takase Masaru, Fukumura Yuki, Suzuki Fujihiko, Jim Atsuro, Kakinuma Chihaya, Tanaka Tsuneo, Matsugu Yasuhiro, Miyasaka Kyoko, Funakoshi Akihiro
Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Pancreas. 2004 Apr;28(3):e86-9. doi: 10.1097/00006676-200404000-00030.
There are many experimental models for chronic pancreatitis. However, it remains unclear which animal models of pancreatic fibrosis can be categorized as chronic pancreatitis models. We compared the histologic features of some animal models of pancreatic fibrosis/chronic pancreatitis and chronic pancreatitis in humans.
Human chronic pancreatitis due to chronic alcohol abuse and unknown etiology showed interlobular fibrosis and a cirrhosis-like appearance. Histopathologically, spontaneous pancreatitis models, WBN/Kob rats and OLETF rats, showed localized/nodular fibrotic lesions, which consisted of swollen, aggregated, atrophic islets of Langerhans; loss of the exocrine parenchyma and hemosiderin deposition that was seldom distributed in the interlobular area. On the other hand, fibrosis in the canine model, which was produced by combining alcohol administration with incomplete pancreatic duct obstruction, was characterized by interlobular fibrosis admixed with a cirrhosis-like appearance very similar to that in human chronic pancreatitis.
Most experimental models for chronic pancreatitis, except alcohol administration combined with other procedures such as incomplete pancreatic duct obstruction, are different from human chronic pancreatitis.
慢性胰腺炎有多种实验模型。然而，哪些胰腺纤维化动物模型可归类为慢性胰腺炎模型仍不明确。我们比较了一些胰腺纤维化/慢性胰腺炎动物模型与人类慢性胰腺炎的组织学特征。
因慢性酒精滥用和病因不明导致的人类慢性胰腺炎表现为小叶间纤维化和肝硬化样外观。组织病理学上，自发性胰腺炎模型，如WBN/Kob大鼠和OLETF大鼠，表现为局部/结节状纤维化病变，由肿胀、聚集、萎缩的胰岛组成；外分泌实质丧失和含铁血黄素沉积，很少分布在小叶间区域。另一方面，通过酒精给药与不完全胰管梗阻相结合产生的犬模型中的纤维化，其特征是小叶间纤维化并伴有与人类慢性胰腺炎非常相似的肝硬化样外观。
除酒精给药与其他操作（如不完全胰管梗阻）相结合外，大多数慢性胰腺炎实验模型与人类慢性胰腺炎不同。
