Khavinson V Kh, Lezhava T A, Malinin V V
St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences.
Bull Exp Biol Med. 2004 Jan;137(1):78-81. doi: 10.1023/b:bebm.0000024393.40560.05.
Effects of synthetic short peptides (Vilon, Epithalon, Livagen, Prostamax, and Cortagen) on activity of ribosome genes, parameters of common heterochromatin melting, polymorphism of structural heterochromatin (C segments) of chromosomes 1, 9, and 16, and variability of facultative heterochromatin were studied in leukocytes of subjects aged 75-88 years. All the studied peptides induced activation of ribosome genes, decondensation of densely packed chromatin fibrils, and release of genes repressed as a result of age-specific condensation of the cellular euchromatin regions (deheterochromatinization of facultative chromatin). Treatment with Epithalon, Livagen, and Prostamax led to decondensation of chromosome 1 pericentromeric structural chromatin, while Epithalon and Livagen treatment led to changes in chromosome 9 as well. Hence, short peptides activate heterochromatin and heterochromatinized regions of cell chromosomes in senile subjects.
研究了合成短肽（维隆、依普他隆、利瓦根、普罗斯塔马克斯和皮质素）对75 - 88岁受试者白细胞中核糖体基因活性、普通异染色质解聚参数、1号、9号和16号染色体结构异染色质（C区段）多态性以及兼性异染色质变异性的影响。所有研究的肽均诱导核糖体基因激活、紧密堆积的染色质纤维解聚以及由于细胞常染色质区域的年龄特异性浓缩而被抑制的基因释放（兼性染色质的去异染色质化）。依普他隆、利瓦根和普罗斯塔马克斯处理导致1号染色体着丝粒周围结构染色质解聚，而依普他隆和利瓦根处理也导致9号染色体发生变化。因此，短肽可激活老年受试者细胞染色体的异染色质和异染色质化区域。
